FERTILITY SUPPLEMENTS THAT REALLY WORK

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Let’s get big-picture and holistic about supplements for a second.

I think it's incredibly ethical and absolutely important to drop the silver-bullet, too-good-to-be-true narrative around things like fixing eggs or overhauling hormones. If fixing infertility were as simple as swallowing the right handful of pills, no one would need IVF. And ditto for curing cancer or any other complicated biological condition.

It's true that smart, select, high-quality supplements can give you a nudge in a positive direction -- which can be wonderful. But I always want you to start from an evidence-based and realistic baseline when it comes to making choices about what supplements to take for infertility -- or for anything really.

If you haven't already watched the Which Fertility Supplements Should I Take? video above, please do. It'll save you a lot of headaches (possibly even literally), not to mention money. Plus, it'll make sure any supplements you do take are legit both from a scientific perspective and from a quality-assurance one too!

It's an easy watch under 13 minutes, and here's what I'm going to cover for you:

  • Dosing considerations

  • Food vs supplements (and food-based supplements)

  • Hormonal side effects

  • Historical times we've gotten it wrong -- a cautionary tale!

  • Quality control or lack of

  • Seriously, what's the goal?

  • Finding evidence-based supplement info

  • Which brands are legit

Disclaimer: All of this information is for educational purposes and should not replace medical care from your trusted team. Always run your options by your doctor or provider to make sure any supplement is a good fit for you, especially if you take prescription medications or have complicated health issues.

Dosing Notes: Where the research supports a clear, consistent dose, I've included it. Where you don't see a dose listed, it's intentional — either the therapeutic range varies widely, the right amount depends on your baseline levels, or the form and brand matter more than a number. Supplements like iron, zinc, and fish oil fall into that category, and giving you a single number there would actually do you a disservice. As always, run anything new by your doctor or provider before starting — especially if you're already on medications, have a complicated health history, or are in an active treatment cycle.

What supplements do I personally sell for fertility?

A lot of people are surprised that my answer to this is NONE. I don't sell any western supplements at my clinic because I believe healthcare providers -- of any type -- should never make extra money by prescribing supplements or medications. This is the ethical standard in Western mainstream medicine, and I strongly believe it should be the same in holistic healthcare too.

If you have a provider selling you 12 supplements -- typically marked up 100% from their wholesale cost -- it's hard to know what's good for you and what's another revenue stream for them. It's a big faux holistic trap.

Supplements should be available via trusted and tested 3rd-party sellers to ensure there's no conflict of interest. That's why I provide the resources people need to buy their supplements on their own with no affiliate ties to me.

So, with all of the big-picture covered, here are some of the supplements I sometimes suggest that may be helpful when taken correctly.

Iron for fertility.

I recommend iron for fertility for:

  • People with iron deficient anemia

  • People with TCM (Traditional Chinese Medicine) blood deficiency patterns (signs include: dizziness and seeing floaters in your vision, hands and feet falling asleep often, difficulty falling asleep, restless sleep, heart palpitations, pale inner eyelids, thin pulse)

  • Folks with scanty or missing menstrual flows

  • Regularly menstruating women, but only 1-2 bottles per year

  • After childbirth, especially with excessive blood loss

  • When there's low milk supply when breast or chest feeding

  • People with insomnia

Brands I recommend: Floradix Liquid Iron and Herbs -- liquid and fabulous, but spoils a month from opening and tastes strongly of iron; Barimelts Iron and C -- melt-away, good taste; Renzos Iron Strong -- melt-away, best for kids or those with sensitive stomachs; NOW Iron or Fergon -- consumer lab-tested and budget-friendly options less likely to cause GI upset.

Floradix Iron has been specifically okayed by the MFM perinatologist group in the Twin Cities for pregnant patients to use. It is great for pregnancy or while trying to conceive, especially if you have thin lining concerns.

Just be careful when it comes to iron supplements. Hemochromatosis is a genetic disorder that leads to too-high iron levels. If you aren't sure what your levels actually are, have your clinic run a test to be sure it's safe for you to add iron to your routine.

Fish Oil for fertility.

I recommend fish oil for fertility for:

  • Decreasing inflammation for immune and pain issues

  • Thinning the blood for circulation or clotting concerns

  • Certain recurring pregnancy loss cases

  • Anyone who doesn't regularly eat fatty fish -- take 2-3 times per week

Brands I recommend: Carlsons, Blue Ice Fermented Cod Oil, Kirkland's Best, and Nordic Naturals. Deva Vegan Omega is vegan and tests high for EPA/DHA without breaking the bank. Nordic Naturals is the brand the American Pregnancy Association endorses.

Vitamin D for fertility.

  • I recommend Vitamin D for fertility for:

  • All lower melanin skinned people living in the Midwest from November-April

  • Breastfed babies and lactating moms

  • People who test under 20 ng/ml (you don't need high Vitamin D -- prior high-dose recommendations are out of date)

Brands I recommend: Kirkland's Best, NOW, Nature's Made, Garden of Life, and Nordic Naturals. Pure Encapsulation or Carlson brands are good liquid options.

Vitamin D is fat soluble, so taking it in a liquid form like medium chain triglyceride oil can help with absorption if you have weaker digestion -- vs a pill or gummy.

Don't overdo it! If your Vitamin D is over 20 ng/ml, you probably don't need more. If it's over 35 ng/ml, you may be doing more harm than good by adding more. Too-high Vitamin D is linked to bone fractures and cancer -- more is not better.

Folic Acid (aka Folate or B9) for fertility.

I recommend folic acid for fertility for:

  • People who are trying to conceive or actively pregnant -- take most days of the week

  • People who have had abnormal pap results -- take at a higher dose

  • Anyone who has taken methotrexate, but only AFTER they are given the okay to start by their MD

  • Those with the MTHFR mutation

  • People who are in their first trimester of pregnancy -- and often beyond

Dosing: Women under 30 should take 400 mcg/day; ages 30-40 should take 800 mcg/day; 40+ or with MTHFR, abnormal paps, or methotrexate history should take 1200+ mcg/day.

Brands I recommend: Jamieson Chewable B Multi is a solid option without super-high doses. Doctor's Best Folate is budget-friendly. New Chapter Fermented B Vitamin Liquid is a good liquid option.

Folate is the naturally occurring form found in food, while folic acid is the synthesized supplement version. Based on the most recent data (and contrary to what social media will say), both are actually equally bioavailable for most people -- you do NOT need to buy expensive 5-methylfolate to get good results.

However, there are two situations where 5-MTHF is worth the upgrade:

Post-methotrexate: Methotrexate works by blocking the enzyme that converts folic acid into its active form, and that pathway can remain compromised even after the medication is discontinued. 5-MTHF bypasses that conversion entirely and arrives already in the active form.

Homozygous MTHFR C677T: This variant can reduce conversion efficiency significantly enough that 5-MTHF is a reasonable preference -- not because folic acid doesn't work, but because you're fighting the conversion inefficiency on top of already needing higher doses. Heterozygous carriers generally do fine with standard folic acid at adequate doses.

Prenatal Vitamins for fertility.

I recommend prenatal vitamins for fertility for:

  • To take regularly for 3 months prior to trying to conceive

  • Every other day or even every 3rd day after that, if you eat a varied diet (or most days if you don't)

Brands I recommend: Smarty Pants Gummies (really!), One a Day Prenatal Advanced (Consumer Lab's current top pick), Nature Made Prenatal + DHA and TheraNatal Complete also test well.

My two cents: I'd much rather a person eat well first, but a reputable prenatal vitamin brand can help make sure nothing is missing.

Probiotics for fertility — really!

I’ve got a whole blog post about probiotics for fertility and pregnancy-specific concerns —as probiotics for fertility is one a lot of folks miss.

I recommend probiotics for fertility for:

  • Anytime you take antibiotics, have a yeast infection, or BV -- Saccharomyces boulardii is your best probiotic option during antibiotics because it's yeast-based and the antibiotic won't kill it OR if you take a more general probiotic take at least 2 hours apart from any antibiotics so they can both work well

  • Those with digestive or anxiety-related main concerns

  • Folks with endometriosis or PID (pelvic inflammatory disease)

  • Everyone every-now-and-then for good measure -- including while pregnant and nursing

Brands I recommend: For vaginal suppositories: VagiBiom (available online and often at CVS, Walmart, Walgreens). For oral options: Align, Culturelle, Jarrow, Swanson, Garden of Life, Nature's Way, RePHresh (for vaginal flora), and Spring Valley all pass quality tests. Rotating various types can be helpful since certain strains address certain issues.

Before taking probiotic supplements, I'd love it if you could also choose unpasteurized fermented foods first. Did you know only one serving of some sauerkrauts has a larger variety and number of beneficial bacteria than an entire bottle of supplements? Try kefir, kombucha, miso soup, sauerkraut, kimchi, fermented vegetables, and yogurt when you can.

Magnesium for fertility.

Magnesium can help with:

  • Relaxing cramping muscles

  • Blocking the chemicals that cause cramps (prostaglandins)

  • Reducing inflammation

  • Turning down pain signals in the nervous system

  • Calming the stress response via cortisol regulation

  • Supporting mood and reducing anxiety

  • Boosting cellular energy production

Keep in mind that magnesium doesn't exist in supplement form as a pure mineral -- it's always attached to something else (glycine, citrate, oxide, etc.) to make it stable and absorbable. That compound has its own weight. So when a label says "Magnesium Glycinate 1000mg," that 1000mg is the weight of the whole molecule -- magnesium plus glycine. The actual magnesium content is only a fraction of that. A capsule labeled "Magnesium Glycinate 1000mg" typically contains around 140mg of elemental magnesium. So when research says "360mg of magnesium daily reduced painful periods," they mean 360mg of the actual mineral (elemental magnesium) -- which might require 2,500mg+ of magnesium glycinate by label weight to achieve.

I recommend magnesium for:

Migraines: magnesium citrate 600mg/day, divided into 2-3 doses

Bad period cramps: magnesium glycinate, 300-400mg elemental magnesium/day. For best results, start mid-cycle rather than only during your period -- it takes time to build tissue levels.

Pregnancy leg cramps: magnesium bisglycinate chelate

Constipation: higher doses of magnesium citrate or oxide

Long-term PPI (heartburn medication) users: PPIs often deplete magnesium, and sometimes supplementation isn't enough to restore normal levels -- talk to me, I have other suggestions if you're afraid to go off PPIs

Trouble falling asleep: magnesium glycinate or Epsom salt baths before bed

Brands I recommend: NOW Magnesiums, Deva Vegan Mag Bisglycinate, and Natural Vitality Calm.

Epsom salt baths and magnesium sprays seem to get magnesium into the body with less digestive or laxative effect. I recommend 2 cups of Epsom salt in a 15-minute bath as needed. Remember, higher doses of any type of magnesium are more likely to cause loose stools.I think it’s incredibly ethical and absolutely important to drop the silver-bullet, too-good-to-be-true narrative around things like fixing eggs or overhauling hormones. If fixing infertility were as simple as swallowing the right handful of pills, no one would need IVF. And ditto for curing cancer or any other complicated biological condition.


And those are my most frequently suggested fertility supplements with the accompanying situations that make me suggest them!

Now, what about all the It Starts with the Egg supplements or suggestions on fertility forums?!

More targeted supplements -- the "if this, then that" tier

The supplements below are more targeted than the ones above -- they tend to be relevant for specific diagnoses, particular patterns of infertility, or situations where there is a clear deficiency. I would not suggest most of these across the board. Think of the list above as broadly useful, and this list as more specialized and situational -- more worth discussing with your provider before adding.

Of course, there's a huge list of other supplements you'll hear suggested. I'm more than happy to talk about lots more in-depth options in-person, and I'm very familiar with the most common suggestions. Here's a little about my take -- in alphabetical order:

Alpha-Lipoic Acid (ALA)

What the research suggests: A broad antioxidant that helps protect eggs and sperm from oxidative damage. Has been studied for subclinical hemorrhage (SCH -- a type of early pregnancy bleeding) with some promising results. Also supports mitochondrial function, which matters for egg quality.

Note: You do NOT need to pay more for the R-form -- the standard form works well.

Brands: Puritan's Pride Alpha Lipoic Acid 200mg

B-12

What the research suggests: Especially important for ovulation -- B12 deficiency has been linked to anovulation (absence of ovulation). An absolute must for vegans and a strong recommendation for most vegetarians, since B12 is found almost exclusively in animal products.

Brands: Mason Natural, Nature Made

B Vitamins (complex)

What the research suggests: Covers the same ground as B12 above, but also includes folate and other B vitamins that support hormonal metabolism, energy production, and nervous system function. Useful when you want broader B coverage rather than targeting B12 alone.

Brands: Kirkland Signature Super-B Complex

Vitamin C

What the research suggests: A water-soluble antioxidant that supports egg and sperm quality by reducing oxidative damage. Also plays a role in progesterone production -- particularly useful for luteal phase deficiency or low progesterone. The corpus luteum (the structure that produces progesterone after ovulation) has one of the highest concentrations of Vitamin C in the body.

Dose: 500-1000mg/day; higher doses tend to cause GI upset and diarrhea -- more is not better.

Brands: Natures Plus Chewable Orange Juice JR, Solaray Vitamin C Powder, Swanson, Microingredients Organic Acerola Powder

Chromium (Picolinate)

What the research suggests: May help improve insulin sensitivity and blood sugar regulation. Most relevant for people with PCOS, type 2 diabetes, or obesity-related infertility -- conditions where insulin resistance is a driver of hormonal disruption.

Brands: 365, EZmelts, GNC, Puritan's Pride, Spring Valley

CoQ10 (Ubiquinol)

What the research suggests: One of the most well-researched fertility supplements. CoQ10 is essential for mitochondrial energy production -- and eggs are among the most mitochondria-dependent cells in the body. Supports both egg quality and sperm motility. Research is most robust for diminished ovarian reserve and advanced maternal age.

Dose: 200-600mg/day of standard CoQ10; for 40+, ubiquinol 100-200mg/day is preferred (it's the pre-converted form your body can use more directly).

Brands: Doctor's Best with Black Pepper, Swanson Ubiquinol (for 40+), Garden of Life Gummy

Vitamin E

What the research suggests: A fat-soluble antioxidant that supports uterine lining development and implantation. Commonly used -- often alongside low-dose aspirin -- for thin lining that is not responding well to estrogen. Also has mild blood-thinning and anti-inflammatory effects and supports hormonal balance more broadly.

Dose: 400 IU/day. Natural form (d-alpha-tocopherol) is significantly better than the synthetic form (dl-alpha) -- worth checking your label.

Note: This is a blood thinner -- watch for unusual bruising or bleeding. More is not better.

Brands: Natural, GNC, Solgar Liquid

L-Arginine

What the research suggests: A precursor to nitric oxide, which dilates blood vessels and improves circulation. Used to enhance blood flow to the uterus and ovaries, which matters for lining development, response to ovarian stimulation medications, and egg quality. Also studied for male factor (improved sperm parameters). Relevant for cases with poor pelvic blood flow, past placental issues, or high-resistance Doppler scans.

Dose: 2-3g/day

Brands: Swanson, Vitacost

L-Carnitine

What the research suggests: Similar territory to CoQ10 -- supports mitochondrial function and energy production in cells. Also studied as an antioxidant for both egg and sperm quality. Some evidence for improving sperm motility specifically. Often used alongside CoQ10 rather than instead of it.

Brands: Bluebonnet, Doctor's Best, Jarrow Formulas

L-Theanine

What the research suggests: Not a direct fertility supplement, but worth mentioning for people whose primary barrier is stress and anxiety. Supports calm focus without sedation. By reducing cortisol and modulating the stress response, it can address a meaningful upstream driver of hormonal disruption -- particularly for people who can't fall asleep or feel chronically wired and exhausted.

Brands: Doctor's Best, Jarrow, GNC, Nature's Trove, Swanson

Myo-Inositol

What the research suggests: Best studied for PCOS and insulin resistance. Inositol is involved in insulin signaling, and supplementation has been shown to improve egg quality, ovulation regularity, and hormonal profiles in PCOS patients. Often paired with D-chiro-inositol at a 40:1 ratio to mirror the body's natural balance.

Dose: 2-4g/day; often combined with D-chiro-inositol at a 40:1 ratio

Brands: NOW

Pycnogenol

What the research suggests: A pine bark extract with potent anti-inflammatory and circulation-improving effects. Studied for endometriosis (where it appears to reduce lesion size and pain) and male factor infertility (improved sperm quality). One of the more interesting supplements in this space -- not yet widely used clinically, but the research is promising enough to pay attention to.

Dose: 100-200mg/day

Note: Look for Pinus pinaster as the source -- other forms are less expensive but not as well-researched. This is one worth spending a little more on.

Selenium

What the research suggests: An important cofactor for thyroid hormone conversion -- relevant because thyroid dysfunction is one of the more common and underdiagnosed contributors to fertility problems. Also an antioxidant. Most beneficial when there is an actual deficiency; food sources like Brazil nuts (just 1-2 per day) cover it efficiently for many people.

Dose: 100-200mcg/day if supplementing -- but check your prenatal first, and don't stack. Selenium toxicity is a real concern at higher doses.

Brands: Spring Valley, 365, NOW, MegaFood, Nature's Way

Zinc

What the research suggests: Essential for egg maturation, sperm production, and testosterone metabolism. Deficiency is linked to poor sperm parameters and disrupted ovulation. Often already included in prenatals at adequate levels -- so check before adding extra, as too much zinc can interfere with copper absorption and become counterproductive.

Brands: Solgar Zinc Picolinate, Vitacost Chelated Zinc Glycinate 30mg, Cold-Eeze Lozenges, Mary Ruth's Liquid Ionic Zinc

Finding reliable supplement information

If you're a Life Healing Life patient, let me know if you'd like to discuss supplements more in-depth. If you'd like to check out the research and hard data on various supplements, Examine.com is a great resource -- it not only compiles the research, but rates each study's strength and notes how much the various studies agree or contradict one another.

I have and will continue to consult ConsumerLab to suggest brands that are of the best quality, most consistent, and most cost-effective.

No matter where you are in your life -- puberty, periods, fertility, pregnancy, perimenopause, menopause -- I hope this gives you a great foundation for all things supplements. Thanks for reading!

Warmly,

Nicole

Portait of Nicole Lange smiling and black floral shirt over light tan background

Nicole Lange

LICENSED ACUPUNCTURIST
HOLISTIC FERTILITY EDUCATOR

Nicole Lange

Licensed Acupuncturist

Holistic Fertility Educator

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